Today, many drug molecules exhibit poor aqueous solubility and bioavailability. There is a need for innovative formulation approaches to improve their performance in drug therapy. Smart drug delivery systems require advanced analytical technology to assure their quality and safety but also to predict the clinical outcomes at an early stage in drug development.
Quality planning consists of developing the products and processes required to meet customer’s needs”
– Joseph M. Juran –
Following a quality-by-design approach our group combines novel formulation technologies with highly advanced drug release models to identify critical quality attributes of drug delivery systems. This allows us to design and to manufacture nanocarriers and nanoparticles at high quality and different scales of production. Additionally, we use advanced in silico models to simulate pharmacokinetics of novel drug delivery systems such as liposomes, nanosuspensions and hot melt extrudates.