About the position
A PhD-student position within the field of nanomedicine is available in the Wacker Research Lab at the Department of Pharmacy of the National University of Singapore. Together with several partners from academia and the pharmaceutical industry, the candidate will work in an interdisciplinary translational research project developing high-end in vitro assays to predict the in vivo performance of nanotherapeutics for the subcutaneous route of administration.
About the research project
Today, many new compounds are characterized by low peroral bioavailability as well as a short plasma half-life. In particular, the rapidly growing market of biopharmaceuticals has been addressed by the development of microparticle and nanoparticle formulations acting as a depot in the interstitial fluid. Although the physiology of the subcutaneous tissue is known, the intertwined kinetic processes which influence pharmacokinetics of the drug have only insufficiently been investigated. Aim of this project is the development of novel formulations of peptides and proteins which resist the physiological environment and can be released into the blood. To test these formulations a novel in vitro release and diffusion assay in combination with physiologically-based pharmacokinetic modeling will be utilized.
Requirements and conditions
The PhD-position’s main objective is to qualify for work in research positions. Admission criteria of the National University of Singapore (including an interview) and the scholarship program must be met.
General admission criteria of research-based programs
Conditions of the NUS scholarship
- A master’s degree or equivalent education within natural sciences (perferably in pharmacy) providing strong skills and knowledge in nanotechnology/engineering, biopharmaceutics, pharmacokinetics.
- A strong academic record of a master or equivalent education
- Excellent English skills, spoken and written
What matters for us?
- The candidates’ personality and motivation for the position
- Ability to work independently as well as in transdisciplinary teams
- It is an advantage to have experience in:
- Biopharmaceutics and PBPK modeling
- In vitro drug release or dissolution testing
- Development or formulation of nanodelivery systems
- R, Stella, GastroPlus, SimCyp, Certara Phoenix
- Personal characteristics:
- Efficient and well organized
In the evaluation of which candidate is best qualified, emphasis will be placed on education, experience and personal suitability, as well as motivation, in terms of the qualification requirements specified in the advertisement
For further information please contact firstname.lastname@example.org including a cover letter, CV and other relevant information (certificates etc.).