Wacker Research Group

Today, many drug molecules exhibit poor aqueous solubility and bioavailability. There is a...

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Our services and research activities all around nanotechnology

Research & Teaching

Our research and teaching activities at the National University of Singapore

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Latest news about our research activities

Collaboration with Innomedica

Together with the Swiss company InnoMedica, @TheWackerLab at the National University of Singapore develops novel performance assays for injectable nanomedicines including their clinical drug candidate Talidox. The strategic collaboration within the Department of Pharmacy is supported by the National Research Foundation of Singapore and the Faculty of Science with a Resilience & Growth Postdoc Fellowship.

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Targeting the Brain

Our latest research article will appear in the journal Molecules soon. Here we explore the pharmacokinetics and in vitro properties of the drug formulations NanoCore-6.4 and NanoCore-7.4. Both polymeric nanocarrier formulations attract lipoproteins endowing them with a lipid-like biological identity. This leads to enhanced uptake in the brain. In the in vivo setting, the capacity of brain uptake depends on the drug release in the blood plasma that constantly reduces the payload of the carrier. Therefore, our simulations contribute to a better understanding of the brain delivery process, qualitatively and quantitatively. Furthermore, we were able to show that a small shift in the drug release had a considerable effect on pharmacokinetics. This is a way to measure the effectiveness of the loading strategy and allows a quality-by-design approach in carrier development.

Kovshova T, Osipova N, Alekseeva A, Malinovskaya J, Belov A, Budko A, Pavlova G, Maksimenko O, Nagpal S, Braner S, Modh H, Balabanyan V, Wacker MG and Gelperina S (2021); Exploring the interplay between drug release and targeting of lipid-like polymer nanoparticles loaded with doxorubicin, Molecules (2021)

#nanomedicines #MoreThanDissolution #WackerLab #ResearchIsInternational #NUSFacultyOfScience

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Merry #VirtualChristmas

An eventful year 2020 ends with a first virtual Christmas.

Thanks to my great team, the #WackerLab has flourished! We moved our equipment twice and were completely digitalized during the Circuit Breaker. Now we are part of the new Wet Science Building Family. Our national and international collaborations have made us much stronger. Who would have known that you could use #ReleaseTesting to estimate the environmental impact of drug products? Also, our predictions of the performance of injectable drug products have reached the next level! We can do everything we want, as long as we are working together! #MerryVirtualChristmas #WackerLab #ReleaseTesting #ScienceIsInterdisciplinary #PeopleDoTheScience #NUSDepartmentOfPharmacy #FacultyOfScience #UnitedWeCan

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