Wacker Research Group

Today, many drug molecules exhibit poor aqueous solubility and bioavailability. There is a...

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Our services and research activities all around nanotechnology

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Our research and teaching activities at the National University of Singapore

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Latest news about our research activities

Targeting the Brain

Our latest research article will appear in the journal Molecules soon. Here we explore the pharmacokinetics and in vitro properties of the drug formulations NanoCore-6.4 and NanoCore-7.4. Both polymeric nanocarrier formulations attract lipoproteins endowing them with a lipid-like biological identity. This leads to enhanced uptake in the brain. In the in vivo setting, the capacity of brain uptake depends on the drug release in the blood plasma that constantly reduces the payload of the carrier. Therefore, our simulations contribute to a better understanding of the brain delivery process, qualitatively and quantitatively. Furthermore, we were able to show that a small shift in the drug release had a considerable effect on pharmacokinetics. This is a way to measure the effectiveness of the loading strategy and allows a quality-by-design approach in carrier development.

Kovshova T, Osipova N, Alekseeva A, Malinovskaya J, Belov A, Budko A, Pavlova G, Maksimenko O, Nagpal S, Braner S, Modh H, Balabanyan V, Wacker MG and Gelperina S (2021); Exploring the interplay between drug release and targeting of lipid-like polymer nanoparticles loaded with doxorubicin, Molecules (2021)

#nanomedicines #MoreThanDissolution #WackerLab #ResearchIsInternational #NUSFacultyOfScience

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Merry #VirtualChristmas

An eventful year 2020 ends with a first virtual Christmas.

Thanks to my great team, the #WackerLab has flourished! We moved our equipment twice and were completely digitalized during the Circuit Breaker. Now we are part of the new Wet Science Building Family. Our national and international collaborations have made us much stronger. Who would have known that you could use #ReleaseTesting to estimate the environmental impact of drug products? Also, our predictions of the performance of injectable drug products have reached the next level! We can do everything we want, as long as we are working together! #MerryVirtualChristmas #WackerLab #ReleaseTesting #ScienceIsInterdisciplinary #PeopleDoTheScience #NUSDepartmentOfPharmacy #FacultyOfScience #UnitedWeCan

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How to predict what happens to long-acting injectables?

First author Ge Fiona Gao explored subcutaneously administered injectables as part of her PhD project

We are very happy to announce that Ge Fiona Gao just got her second first-author paper accepted by the Journal of Controlled Release. Our investigation of the drug release from PLGA microspheres highlights the need for biorelevant conditions to simulate degradation effects and predict bioavailability. Our international team of authors from Germany, Singapore, and Japan established in vitro-in vivo correlations for two drug formulations of tacrolimus. The formulations were tested in biorelevant medium in presence of protein background using the DR technology. To establish the IVIVC, a drug recovery model and a membrane permeation model were used and the fraction released in the in-vitro system was calculated. Mechanistic understanding of the physiological processes was gained by means of an in-silico model reflecting the absorption mechanisms in the subcutaneous tissue. The interplay between release, drug diffusion, lymphatic transport, and degradation plays a key role in the performance of injectables that remain in the subcutaneous tissue for a longer time period. Once production is over, the manuscript will become available under:


Gao GF, Ashtikar M, Kojima R, Yoshida T, Kaihara M, Tajiri T, Shanehsazzadeh S, Modh H, Wacker MG (2020); Predicting drug release and degradation kinetics of long-acting microsphere formulations of tacrolimus for subcutaneous injection, J Control Release (Accepted for publication) 


#releasetesting #morethandissolution #NUS #FacultyOfScience #wackerlab


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