Wacker Research Group

Today, many drug molecules exhibit poor aqueous solubility and bioavailability. There is a...

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Our services and research activities all around nanotechnology

Research & Teaching

Our research and teaching activities at the National University of Singapore

Lab @ ResearchGate

The activities of our lab is accessible on ResearchGate.

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Latest News

Latest news about our research activities

How to predict what happens to long-acting injectables?

First author Ge Fiona Gao explored subcutaneously administered injectables as part of her PhD project

We are very happy to announce that Ge Fiona Gao just got her second first-author paper accepted by the Journal of Controlled Release. Our investigation of the drug release from PLGA microspheres highlights the need for biorelevant conditions to simulate degradation effects and predict bioavailability. Our international team of authors from Germany, Singapore, and Japan established in vitro-in vivo correlations for two drug formulations of tacrolimus. The formulations were tested in biorelevant medium in presence of protein background using the DR technology. To establish the IVIVC, a drug recovery model and a membrane permeation model were used and the fraction released in the in-vitro system was calculated. Mechanistic understanding of the physiological processes was gained by means of an in-silico model reflecting the absorption mechanisms in the subcutaneous tissue. The interplay between release, drug diffusion, lymphatic transport, and degradation plays a key role in the performance of injectables that remain in the subcutaneous tissue for a longer time period. Once production is over, the manuscript will become available under:


Gao GF, Ashtikar M, Kojima R, Yoshida T, Kaihara M, Tajiri T, Shanehsazzadeh S, Modh H, Wacker MG (2020); Predicting drug release and degradation kinetics of long-acting microsphere formulations of tacrolimus for subcutaneous injection, J Control Release (Accepted for publication) 


#releasetesting #morethandissolution #NUS #FacultyOfScience #wackerlab


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Beilstein Talk: Nanomedicine

Established by the Max Planck Society in 1951, the Beilstein Institute is a non-profit organization promoting the chemical sciences. Today it publishes the free-of-charge Beilstein Journal of Nanotechnology. During the COVID pandemic, researchers made their results accessible in times of crisis and we all found value in science without barriers. This is why I am happy to support the foundation by giving the first in a series of Beilstein Talks. On the 18th of November 2020, 9 pm Singapore time (2 pm CET) I will present:

“Nanomedicine at the crossroads: Why good chemistry is not enough”

Please join the virtual event and hear my critical reflection on nanotechnology research and why interdisciplinary approaches are needed to improve current design strategies…

CLICK HERE TO REGISTER

#sciencewithoutbarriers #releasetesting #wackerlab #nanomedicine

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